Prednisolone (Wysolone) :

Side-effect :

It may cause bone-marrow suppression which causes the hemoglobin level t drop down.
A 'missed' dose should be taken at least six hours before the next dose is due. If there is less than six hours before your next dose do not take the 'missed' dose. Never try to make up by doubling the doses. Sirolimus, Everolimus (Rapammune, Certican)
Everolimus is a newer drug that helps reduce acute rejection. Its main advantage is that it is not nephrotoxic and is accociated with a lower incidence of CMV (Cytomegalovirus) infection. It acts synergistically with cylosporine to prevent organ rejection and prolong the graft (transplanted kidney) survival. Everolimus and Cyclosporine are to be given at the same time.


Weakening of bones (osteoporosis/osteoporosis). Calciumsupplements are prescribed to prevent this.10IL-2 Inhibtors (Zenapax, Simulect)Simulect and Zenapaz are two IL-2 inhibitors that has been shown to reduce the incidence of acute rejection in the first six months. They are expensive and you should discuss with you doctor whether you should be on this induction therapy or not.

Some of the following drugs will be included in your prescription:

Anti ulcer drugs : Ranitidine (Rantac), 'Digene'
Some of immunosuppressants prescribed can lead to irritation of the stomach, and in a small proportion of patients ulcer formation (hence Prednisolone and Azathioprine are taken after food).

Anti-hypertensives :

Amlodepin, Atenolol, Minipress- XL (Prazosin), Arkamine (Clonidine), Betaloc Some patients will need to take medicines to lower the blood pressure which may be caused by the medications. Calcium supplements : Shelcal, alpha D-3, cholecalciferol granules.Calcium may be given to trengthen your bone which weakens gradually due to long term steroid (prednisolone) intake. A drugelandronate (Osterophos) may be prescribed if obsteopenia or osteoporosis is diagnosed.Antibiotics, antifungals, antivirals. As the immunosuppressive drugs increase the risk of infections, you may be prescribed antibiotics, antifungals or antivirals accordingly. In general, the strict diet limitation patients may face pre-transplant do not apply post-transplant. Following transplantation, patients should limit the amount of fat and cholesterol in their diet because anti-rejection medications and the liberalized diet can cause elevated cholesterol and fat levels. Patients also need to be careful of weight gain that may occur from anti-rejection medications( prednisolone) which causes dramatic increase in appetite.